Acitretin API ke eng?

Acitretin API, ke lithethefatsi tse entsoeng ka vithamine A, tse tsejoang hape e le all-trans retinoic acid kapa betarretin A. E laola hore na lisele tse ngata tsa letlalo li ata le ho khetholla ha li ntse li ama tsela eo stratum corneum e tsoelang pele ka eona. E ntlafatsa mathata a kang keratosis, e fokotsa makhopho, 'me e laola mebala ea letlalo ka ho hokela ho receptor ea vithamine A e khubung ea lisele le ho fetola mongolo oa liphatsa tsa lefutso le polelo ea protheine. Ka boima ba molek'hule ea 326.43 g / mol le mokhoa oa lik'hemik'hale oa C21H26O3, Hangata e nka mofuta oa kristale e mosehla kapa phofo ea kristale. E na le nomoro ea CAS 55079-83-9. Hexane e ka sebelisoa ho e tiisa, 'me ntlha ea eona e qhibilihang ke 228 - 230 °C. LD50 ka ente ea intraperitoneal e tloha ho> 4000 mg/kg(letsatsi le le leng) ho isa ho 1 mg/kg(matsatsi a 700 le matsatsi a 10), ho latela lipatlisiso tsa chefo e matla ho litoeba. Metabolite e sebetsang ea tretinoin ke acitretin, motsoako o monate oa maiketsetso oa vithamine A. Ho phaella maemong a mang a letlalo, e sebelisoa ho phekola psoriasis e matla le keratosis.

Information Basic 

Lebitso la sehlahisoa: Acitretin

CAS: 55079-83-9

MF:C21H26O3

MW: 326.43

EINECS: 259-474-4

Nomoro ea MDL: MFCD00866632

Sebaka se qhibilihang: 228-230°C

Sebaka se belang:404.46°C (khakanyo e boima)

Density 1.1348 (khakanyo e fosahetseng)

refractive index 1.4700 (khakanyo)

mocheso oa polokelo. -20°C

Botsitso: E tsitsitseng

Mokhoa o raliloeng:

Tekanyetso ea boleng 

Mosebetsi le Tshebediso

Acitretin API ke moriana o nooang oa sehlopha sa retinoid sa lithethefatsi. E sebelisoa haholo ho phekola maemo a fapaneng a letlalo, haholo-holo psoriasis e matla (severe plaque psoriasis), mathata a keratinization, le palmoplantar keratoderma.

Lenane le latelang ke lenane la ts'ebeliso ea eona le mesebetsi:

• Phekolo ea Psoriasis: e fokotsa ho hlohlona, ​​ho ruruha, matheba a mafubelu le mahlaba a manonyeletso a amanang le psoriasis. E laola karohano ea lisele le ho ata, e fokotsang keratinization e feteletseng le karabelo ea ho ruruha le ho fokotsa ho teba ha psoriasis.

• Kalafo ea mathata a keratinization: e ka sebelisoa ho phekola loricrin keratoderma le non-epidermolytic palmoplantar keratoderma. Matšoao le ponahalo ea letlalo li ntlafatsoa ka ho fokotsa keratinization ea letlalo.

• Kalafo ea palmoplantar keratoderma: e ka alafa palmoplantar keratoderma ka ho fokotsa botenya le boemo ba keratinization liatleng le maotong, ho fokotsa matšoao a bohloko bo joalo, maphao le ho eketsa keratinization.

E ka baka litla-morao nakong ea kalafo, joalo ka molomo o omileng, cheilitis, matšoao a mahlo, le ts'ebetso ea sebete e fetotsoeng, ka hona ho bohlokoa ho hlokomela sena. Ka lebaka leo, e lokela ho sebelisoa tlas'a tlhokomelo ea ngaka, ka tlhahlobo e tsoelang pele ea katleho le polokeho ea eona. hape ha e khothalletsoe ho sebelisoa ke basali ba lebeletseng kapa ba anyesang hobane e ka lematsa lesea le ka pōpelong kapa masea a sa tsoa tsoaloa.

Liphetoho tse bohloko

Melomo e omileng, cheilitis, angular stomatitis, mucosa ea molomo e omileng kapa e halefileng, le epithelium ea nakoana ke matšoao a maemo a phahameng a vithamine A. Ho se mamelle ho kopana le lilense, keratitis, seso sa cornea, le conjunctivitis. matšoao a ho ruruha mala. lenyora le mofufutso. ho hlotheha ha moriri ho phekolehang. letlalo le lesesane ebile le hlaba. Paronychia, kholo e sa tloaelehang ea manala, granuloma, 'me ka linako tse ling ho opeloa ha masapo, manonyeletso le mesifa. Ho fokotseha ha lipoprotein tse phahameng, ho eketseha ha triglycerides le k'holeseterole, ho phahamisa li-transaminase le alkaline phosphatase. Matšoao a eketsehang a khatello ea kelello a kenyelletsa hlooho, pono e lerootho, calcification e feteletseng, extraosseous calcification, osteoporosis, le ho koaloa ha poleiti ea pele ea epiphyseal.

Mokhoa oa tlhahiso

4-methoxy-2,3,6-trimethylbenzaldehyde (Ⅰ) le ethyl formate e arabela ka phosphoric e nang le ethanol ho hlahisa motsoako (Ⅱ) ka lihlahisoa tsa 84%. Ebe, e sebetsana le (Ⅲ) ho ethyl acetate e nang le zinc chloride ho hlahisa motsoako oa 6:4 (E)-(Ⅳ) le (Z)-(Ⅳ), ka kakaretso ea 83%. Phaliso ea asiti e fana ka 27% ea (E,E)-(V) le 21% ea (Z,E)-(V). (E,E)-(V) e sebetsana le acetone ka har'a motsoako oa methanol-metsi ho hlahisa 25% ea motsoako (Ⅵ). E sebetsana le ethoxyyethynylmagnesium bromide Grignard reagent in ether ho hlahisa motsoako (Ⅶ) ka lihlahisoa tsa 48%. Qetellong, hydrolysis e hlahisa sehlahisoa sa 91%.

Botsitso & polokelo

E tsoa ho vithamine A acid. Maemo a eona a botsitso le a polokelo ke a latelang:

Botsitso: E ka ba e tsitsitseng ka nako e telele ha e bolokiloe maemong a omileng, a sirelelitsoeng ke khanya le a tiisitsoeng. Leha ho le joalo, e na le kutloelo-bohloko ho khanya 'me e ka theola habonolo le ho lahleheloa ke ts'ebetso ha e pepesehetse leseli. Ho feta moo, E boetse e na le maikutlo a mocheso o phahameng le oksijene, e ka fokotsang botsitso ba eona.

Maemo a polokelo: Ho netefatsa botsitso ba eona, ho khothaletsoa maemo a latelang a polokelo:

• Mocheso: E boloke mocheso oa kamore (15°C - 30°C).

• Mongobo: Boloka boemo ba mongobo o batlang o le tlase mme o qobe maemo a mongobo.

• Leseli: E behe ka lijaneng tse sirelelitsoeng khanya ho thibela khanya e tobileng.

• Packaging: Sebelisa lijana tse tiisitsoeng kapa thepa ea ho paka ho etsa bonnete ba ho koala hantle.

Ho paka le ho tsamaisa ka sekepe

itokisa: 1kg / mokotla oa foil; 5kg / carton; 25kg / fiber drum; kapa ho paka joalo ka kopo ea hau.

Tlhophiso:Letšoao le ikhethileng; sephutheloana se ikhethileng; Ho etsa litšoantšo

Ho tsamaisa ka sekepe:

tefo Nako

Ke Hobane'ng ha U Khetha Xi'an Yihui?

Tlhaloso ea bareki

Litifikeiti tsa Xi'an Yihui

Feme ea Xi'an Yihui le Botoro

Melemo ea Rōna

Phihlelo e ruileng: re na le Lilemo tse 13 tsa boiphihlelo ba litsebi;

Bareki lefatšeng ka bophara: rekisetsa linaha tse fetang 100;

Fana ka lihlahisoa tse fapa-fapaneng: lihlahisoa li sebelisitsoe ho mefuta eohle e meholo ea machaba lefapheng la lithethefatsi, lijo tsa lijo, litlolo, phepo ea liphoofolo le lijo tse sebetsang hantle.

Theko esale pele: MOQ e tlase ka theko ea tlholisano;

Setifikeiti sa boleng: ISO; Halal; Kosher e netefalitsoe

Tšebeletso ea ka mor'a thekiso: Sehlopha sa litsebi lihora tse 7 * 24 tšebeletso ea bareki.

Ha re phethela

Ka kakaretso, joalo ka setsebi Acitretin API moetsi, re na le thekenoloji e tsoetseng pele, melemo e mengata, boleng bo holimo, boiphihlelo bo bongata ba tlhahiso, le lits'ebeletso tse ntle haholo. Melemo ena e tla etsa hore e hlahelle tlholisanong ea 'maraka le ho hapa tšepo le tšehetso ea bareki. haeba u e hloka, pls ikutloe u lokolohile ho ikopanya le rona neng kapa neng. re tla u araba kapele.

lintlha tsa rona tsa ho ikopanya:

E-mail: sales@yihuipharm.com

Tel: 0086-29-89695240
WeChat kapa WhatsApp: 0086-17792415937

Hot Tags: Acitretin API,55079-83-9, Acitretin, Suppliers, Manufacturers, Factory, Bulk, Theko, Wholesale, In Stock, Free Sample, Pure, Natural