2-Deoxy-D-glucose powder Supplier

Xi'an Yihui Company ke setsebi moetsi oa molemo ka ho fetisisa 2-Deoxy-D-glucose phofo. Re ka hlahisa 2DG ka litaba tsa 99.9%. E ka sebelisoa lijong, meriana, linthong tsa tlhokomelo ea bophelo, kapa litlolo 'me e finyella litekanyetso tsa USP, BP, EP, CP. Re ka u fa lihlahisoa tsa boleng bo phahameng ka ho fetesisa ka litefiso tsa tlholisano. Khetho ea hau e ntle ka ho fetisisa bakeng sa morekisi ea tšepahalang oa 2DG ke Khamphani ea Xi'an Yihui!

Phofo ea 2-Deoxy-D-glucose ke eng?

2- Deoxy-D-glucose phofo ke ntho ea lik'hemik'hale, mokhoa oa eona oa lik'hemik'hale ke C6H12O5 'me boima ba molek'hule ke 164.16 g / spook, CAS ea eona NO. ke 154-17-6. Ke tsoekere e nang le khabone e tšeletseng e ts'oanang le tsoekere, empa e haelloa ke sehlopha sa hydroxyl ho snippet e 'ngoe ea khabone, ka hona e bitsoang "deoxy" glucose. Ke demitasse e tšoeu e nang le ho qhibiliha ha tlase metsing. 2DG ke moferefere oa metabolic oa kliniki o ka thibelang ho nkela le ho sebelisoa ha tsoekere ea sele, e leng se lebisang ho theoheng ha maemo a ATP ka har'a lisele.

Setlhare sena se sebetsa haholo liseleng tsa tumor le likokoana-hloko tse itseng tse itšetlehileng ka tsoekere e le karolo ea tsona ea mantlha ea metabolic. Ho sebelisa 2DG ho ka etsa hore lisele tsena li shoe kapa li liehe sekhahla sa kholo ea tsona. Ho feta moo, 2DG e sebelisoa e le sesebelisoa ho lipatlisiso tsa neuroscience le metabolism hobane e ka etsisa boemo ba mokhathala oa metabolic, e senola lintlha tsa litsela tsa metabolic tsa cellular.

Ho sibolloa ha 2- Deoxy-D-glucose ho ka saloa morao ho tloha mathoasong a lilemo tsa bo-1950. Ka nako eo, bo-ramahlale ba Amerika Haskell Smith le Morris Ficher ba ile ba sibolla emulsion e bitsoang 2-deoxyglucose ha ba ntse ba ithuta mekhoa ea ho amohela tsoekere ea lisele. Hamorao, rasaense e mong Takashi Otsuka o ile a fumana hore tsoekere ea 2-deoxy e ka kena-kenana le metabolism ea tsoekere ea sele le ho thibela karohano ea lisele nakong ea ho kopana ha DNA.

Hamorao, bo-rasaense ba ile ba etsa lipatlisiso tse eketsehileng ka 2-DG phofo le ho theha hore e ka thibela kholo ea lisele tse itseng le likokoana-hloko ha e ntse e e-na le thepa e fokolang liseleng tse tloaelehileng.

Ho ntlafatsa ts'ebetso ea 2DG, bo-ramahlale ba ile ba qala ho rala le ho etsa li-motes tse tšoanang. Ts'ebetsong ena, ba ile ba theha hore 2DG e ne e le tšitiso e sebetsang haholoanyane ea metabolism, e khonang ho thibela ho kenngoa ha tsoekere ea sele le ho sebelisoa ka katleho. Hajoale, 2DG e fetohile sesebelisoa sa bohlokoa sa liteko le sethethefatsi sa bongaka.

Information Basic

Tekanyetso ea boleng

Mokhoa oa Synthesis

Mokhoa oa ho kopanya oa 2-deoxy-D-glucose phofor e kenyelletsa mehato e 'meli:

Mohato oa pele, tsoekere e kenngoa tlas'a Knoevenagel condensation ka ho itšoara ka methyl vinyl ketone ho hlahisa motsoako oa α, β-unsaturated carbonyl.

Mohato oa bobeli, tThe motsoako oa unsaturated o fokotsehile ho sehlahisoa se lebisitsoeng sa 2-deoxy-D-glucose ka ho fokotsa hydrogenation.

Mona ke mekhoa e khethehileng ea karabelo:

Mohato oa pele oa reaction equation:

Glucose + Methyl vinyl ketone → α,β-unsaturated carbonyl motsoako

Mohato oa pele oa karabelo:

Tlas'a maemo a alkaline, tsoekere le methyl vinyl ketone li sebetsa e le li-nucleophilic reaagents 'me li feta Knoevenagel condensation ka thuso ea thioacetone kapa sodium hydroxide, e hlahisang motsoako oa α,β-unsaturated carbonyl.

Mohato oa bobeli oa reaction equation:

α,β-unsaturated carbonyl motsoako + Hydrogen gas + Catalyst → 2-deoxy-D-glucose

Mohato oa bobeli oa karabelo:

Ka pel'a khase ea hydrogen le catalyst, the-unsaturated carbonyl emulsion ke hydrogenated ho hlahisa 2-deoxy-D-glucose. Sesebelisoa sa mantlha se ts'oanang le platinamo kapa tlhokomeliso hangata se sebelisoa bakeng sa karabelo ena ea hydrogenation.

Ho lokela ho hlokomeloe hore ke mokhoa o le mong feela o tloaelehileng oa ho kopanya 2-deoxy-D-glucose. Ha e le hantle, ho na le litsela tse ling tse fapaneng tsa maiketsetso, tse ts'oanang le phetoho ea lik'hemik'hale tsa uracil le microbial metabolism.

ke motsoako oa bohlokoa haholo o sebelisoang haholo ho tsa bongaka, biotechnology, le indasteri ea lijo. Melemo e meng ea eona ke ena:

Ha e na litla-morao tse chefo 'meleng oa motho' me e na le phello e khethollang ea ho bolaea lisele tsa mofetše;

E na le anti-virus, antifungal, anti-diabetes, anti-bobesity le liphello tse ling;

E ka monngoa le ho sebelisoa ke 'mele oa motho;

E ka sebelisoa e le sesebelisoa sa radiolabeled kapa sesebelisoa sa tokiso ea DNA ho biotechnology;

E ka sebelisoa e le sweetener ea khalori e tlaase indastering ea lijo;

Ka bokhutšoanyane, ke motsoako oa bohlokoa haholo o nang le lits'ebetso tse fapaneng.

Mosebetsi oa 2 Deoxy Glucose ke Ofe?

2 deoxy glucose(2DG) ke analogue ea tsoekere e haelloang ke sehlopha sa hydroxyl sebakeng sa 2 sa selikalikoe sa tsoekere. Hangata e sebelisoa liphuputsong tsa mahlale e le sesebelisoa sa ho lekola metabolism ea tsoekere le litsela tse amanang le eona. Mesebetsi ea eona ke ena:

1. Letlotlo la glycolysis 2DG le nkoa ke lisele ka lipalangoang tsa tsoekere le phosphorylated ke hexokinase ho ea ho 2DG-6-phosphate, e ke keng ea sebelisoa ho feta ka glycolysis. kahoo, 2DG e ka thibela ka tlhōlisano ho kenngoa ha tsoekere le glycolysis, e leng mohato oa pele oa metabolism ea matla.

2. Debaser of autophagy Autophagy ke mokhoa oa ho fokotseha ha cellular o thusang ho boloka cellular homeostasis ka ho tsosolosa liprotheine tse senyehileng kapa tse sa batleheng le li-organelles. 2DG e etsa hore ho be le autophagy ka ho thibela sepheo sa mammalian sa rapamycin (mTOR) tsela, e lebisang ts'ebetsong ea liphatsa tsa lefutso tse amanang le autophagy.

3. Radiosensitizer: Lisele tsa kankere li na le tsoekere e phahameng ea tsoekere le glycolytic flux ho feta lisele tse tloaelehileng, tse tsejoang e le phello ea Warburg. Ka hona, 2DG e ka khetha lisele tsa mofetše ho radiotherapy ka ho thibela glycolysis le ho ntlafatsa likarabo tsa khatello ea maikutlo.

4. Qeto ea ho lokisa maemo a neurodegenerative 2DG e bonts'itsoe ho ntlafatsa ts'ebetso ea kelello le ho fokotsa lefu la methapo ea kutlo mefuteng ea libata tsa tletlebo ea Alzheimer's le tletlebo ea Parkinson. Sena se ka ama ka lebaka la ntlafatso ea metabolism ea tsoekere bokong, ho fokotsa ho ruruha ha neuronal le khatello ea oxidative.

5. Sesebelisoa sa ho ngola metabolic Ka lebaka la sebopeho sa eona se kang tsoekere le bokhoni ba ho hokahana le glycolysis, 2-deoxy-d-glucose API e ka sebelisoa e le lesupa la metabolic ho ithuta pheletso ea metabolism ea li-motes tse hlahisitsoeng ke tsoekere liseleng le li-apkins.

Ka kakaretso,2-deoxy d glucose e na le mesebetsi e mengata ea bohlokoa liphuputsong tsa mahlale, ho kenyelletsa e le inhibitor ea glycolysis, inducer of autophagy, radiosensitizer, monyetla oa kalafo bakeng sa mafu a neurodegenerative, le sesebelisoa sa ho ngola mabitso a metabolic. Lisebelisoa tsa eona li na le litlamorao tse ka bang teng ho saense ea mantlha le meriana ea bongaka.

Ho paka le ho tsamaisa ka sekepe

Paka:1kg / mokotla oa foil; 5kg / carton; 25kg / fiber drum; kapa ho paka joalo ka kopo ea hau.

Tlhophiso:

Letshwao le hlophisitsoeng

Phuthelo e hlophisitsoeng

Graphic customization

Nako ea ho etella pele: Matsatsing a 3 a mosebetsi ka mor'a ho fumana tefo.

Ho tsamaisa ka sekepe

tefo Nako

Ke Hobane'ng ha U Khetha Xi'an Yihui?

Tlhaloso ea bareki

Litifikeiti tsa Xi'an Yihui

Molemo oa rona

Phihlelo e ruileng: re na le Lilemo tse 13 tsa boiphihlelo ba litsebi;

Bareki lefatšeng ka bophara: rekisetsa linaha tse fetang 100;

Fana ka lihlahisoa tse fapa-fapaneng: lihlahisoa li sebelisitsoe ho mefuta eohle e meholo ea machaba lefapheng la lithethefatsi, lijo tse tlatsetsang lijong, litlolo, phepo ea liphoofolo, le lijo tse sebetsang hantle.

Theko esale pele: MOQ e tlase ka theko ea tlholisano;

Setifikeiti sa boleng: ISO; Halal; Kosher e netefalitsoe

Tšebeletso ea ka mor'a thekiso: Sehlopha sa litsebi lihora tse 7 * 24 tšebeletso ea bareki.

Ha re phethela

Ka kakaretso, joalo ka setsebi 2-Deoxy-D-glucose phofo moetsi, re na le thekenoloji e tsoetseng pele, melemo e mengata, boleng bo holimo, boiphihlelo bo bongata ba tlhahiso, le lits'ebeletso tse ntle haholo. Melemo ena e tla etsa hore e hlahelle tlholisanong ea 'maraka le ho hapa tšepo le tšehetso ea bareki.

Haeba u batla ho tseba haholoanyane ka 2-DG kapa o thahasella ho e reka, o ka ikopanya le rona ka nako efe kapa efe. Re tla u araba kapele kamoo ho ka khonehang ka mor'a hore re bone molaetsa.

lintlha tsa rona tsa ho ikopanya:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat kapa WhatsApp: 0086-17792415937

Hot Tags:2-Deoxy-D-glucose powder,154-17-6,2-DG powder, 2-deoxy-d-glucose API,2-deoxy d glucose, Bafani, Baetsi, Feme, Bongata, Theko, Morekisi, In Stock, Free Sample, E hloekileng, ea Tlhaho